Polyfluorinated phosphine ligands in the room temperature Suzuki cross-coupling reactions

Polyfluorinated phosphine ligands can be obtained by regioselective nucleophilic aromatic substitution on tetrafluoronaphthalene derivatives. The ligand efficiency has been demonstrated in the room temperature Suzuki coupling reactions of aryl bromides and aryl boronic acids. The described process allows access to a new class of highly versatile fluorinated phosphine ligands.