کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5278965 | 1385615 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selective mono N-alkylations of cyclen in one step syntheses
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this Letter, we describe selective one step mono N-alkylations of cyclen (1,4,7,10-tetraazacyclododecane) using a range of functionalized alkyl halides. This 'easy to use' synthesis gives rise to mono-derivatives of cyclen from various alkyl halides or, when using alkyl dihalides, bis-cyclen derivatives, where the alkyl group links two cyclen macrocycles together. While the reaction conditions require the use of 1:4 stoichiometry (alkyl halide:cyclen), any unreacted cyclen can be recovered with an aqueous extraction and successfully reused. This procedure was found to be quite versatile, being particularly well-suited for cyclen targets bearing protected thiol groups, as well as α-chloroamide-derived chromophores; such cyclen pendant chromophores are employed as antennae for lanthanide luminescence probes and sensors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 48, Issue 45, 5 November 2007, Pages 8052-8055
Journal: Tetrahedron Letters - Volume 48, Issue 45, 5 November 2007, Pages 8052-8055
نویسندگان
Julien Massue, Sally E. Plush, Célia S. Bonnet, Doireann A. Moore, Thorfinnur Gunnlaugsson,