کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5279085 | 1385618 | 2006 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A mild and efficient one pot synthesis of 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides A mild and efficient one pot synthesis of 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides](/preview/png/5279085.png)
A convenient one pot method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from acids and acyl hydrazides is reported. Acid activation with CDI, followed by coupling with the desired acylhydrazide and dehydration in the same pot with Ph3P and CBr4 affords the corresponding 1,3,4-oxadiazoles in good yield. The scope of the acid and acylhydrazide components is presented.
A convenient one pot method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides is reported. Acid activation with CDI and coupling with the desired acylhydrazide followed by dehydration in the same pot with Ph3P and CBr4 affords the corresponding 1,3,4-oxadiazoles in good yield. The scope of the acid and acylhydrazide components is presented.
Journal: Tetrahedron Letters - Volume 47, Issue 28, 12 July 2006, Pages 4827-4830