A new synthesis of combretastatins A-4 and AVE-8062A

Combretastatins A-4 and AVE-8062A have been synthesized by coupling 3,4,5-trimethoxyphenylacetylene with the corresponding iodomethoxyphenol and bromomethoxyaniline, followed by hydrolysis of the thermally-stable Ti(II)–alkyne complexes.

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