Decomplexation–nitroso Diels–Alder (NDA) approach to C,D-ring functionalisation for hippeastrine

A tandem decomplexation–nitroso Diels–Alder (decomplexation–NDA) procedure has been shown to give the regiocontrol and stereocontrol needed for application in an organoiron-mediated synthesis of the alkaloid hippeastrine, using a selection of nitrosoarenes with functionality present to facilitate removal of the arene after the NDA step.

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