Formal synthesis of fostriecin by a carbohydrate-based approach

The formal synthesis of fostriecin starting from d-glucose, involves chelation-controlled addition, Wittig rearrangement, ring closing metathesis and iodomethylenation, as described.

A formal synthesis of fostriecin, starting from d-glucose involves chelation-controlled addition, Wittig rearrangement, ring closing metathesis and iodomethylenation.