Expeditious synthesis of the aromatic spiroketal skeleton using hetero-Diels-Alder cycloaddition

The hetero-Diels-Alder reactions of enolic ethers generated from methylenation of various esters are described, which allow for the rapid synthesis of various substituted [6,6] aromatic spiroketal skeletons.

The hetero-Diels-Alder reactions of enolic ethers generated from methylenation of various esters are described, which allow for the rapid synthesis of various substituted [6,6] aromatic spiroketal skeletons.