Chemo-enzymatic short-step total synthesis of symbioramide

Natural (2S,3R,2′R)-form of symbioramide and its (2R,3S,2′R)-isomer was directly synthesized by lipase-catalyzed coupling between erythro-(±)-dihydrosphingosine and (R)-2-hydroxyester, both of which were derived from common intermediate, methyl (±)-trans-2,3-epoxyoctadecanoate.