A one-pot process for the regioselective synthesis of 1,3,4-trisubstituted-1H-pyrazoles

A three-step, one-pot process for the regioselective production of 1,3,4-trisubstituted-1H-pyrazoles has been developed, exploiting readily available and cheap raw materials. The process is operationally simple and has been applied to a range of examples, with yields of 30-49% being obtained.