On the use of the modified Julia olefination for bryostatin synthesis

Modified Julia olefination reactions using aldehyde 27 and the benzothiazol-2-yl sulfones 13 and 39 provide efficient syntheses of alkenes 28 and 42, which are advanced intermediates for syntheses of bryostatins.

The modified Julia olefination is used to prepare advanced intermediates for convergent syntheses of bryostatins.