Solid base-catalyzed synthesis of 5-substituted 4,5-dihydroisoxazoles

We present a new synthetic route for the preparation of 5-substituted 4,5-dihydroisoxazole derivatives starting from ethyl nitroacetate and alkenes in the presence of modified Mg:Al 3:1 hydrotalcite.

A new, synthetic method for the preparation of 5-substituted 4,5-dihydroisoxazoles starting from ethyl nitroacetate and alkenes in the presence of hydrotalcite is described.