Chelation-controlled reduction: an enantioselective synthesis of (−)-tarchonanthuslactone

The total synthesis of tarchonanthuslactone (1) has been achieved by two different routes. In the first approach, LiAlH4-LiI reduction and RCM protocols, and in the second approach, Wacker oxidation and LiAlH4-LiI reduction were used as key steps.