Fluorous 2-chloropyridinium salt (Mukaiyama condensation reagent) for amide formation reactions

A new fluorous 2-chloropyridinium hexafluorophosphate was prepared as a modified Mukaiyama condensation reagent, and it was applied in amide formation reactions. Good to excellent purities of amides were obtained after fluorous solid-phase extraction of reaction mixtures without additional chromatography.

A new fluorous 2-chloropyridinium salt was prepared, and was applied in amide formation reactions.