Reductive amination with 5-ethyl-2-methylpyridine borane

We report a new amine borane, 5-ethyl-2-methylpyridine borane complex (PEMB) useful for reductive aminations of ketones and aldehydes in methanol or neat. Two of the three hydrides on PEMB are effectively utilized maximizing the economy of the reagent.

We report a new amine borane, 5-ethyl-2-methylpyridine borane complex (PEMB), useful for reductive aminations of ketones and aldehydes in methanol or neat. Two of the three hydrides on PEMB are effectively utilized maximizing the economy of the reagent.