Chemoselective TBS deprotection of primary alcohols by means of pyridinium tribromide (Py·Br3) in MeOH

A catalytic amount of pyridinium tribromide (Py·Br3) in MeOH chemoselectively deprotects primary TBS ethers in the presence of a variety of other protecting and common functional groups in modest to excellent yields when performed at 0 °C.

Chemoselctive deprotection of TBS and TES ethers with Py·Br3 in MeOH in the presence of other functional groups is described.