The first total synthesis of sequosempervirin A through an orthoester Claisen rearrangement-ring closing metathesis sequence

The first total synthesis of sequosempervirin A, a norlignan with a unique spirocyclic structure has been accomplished using an orthoester Claisen rearrangement-ring closing metathesis sequence.

The first total synthesis of sequosempervirin A, a norlignan with a unique spirocyclic structure is described.