کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5281103 | 1385662 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Water as an efficient medium for the synthesis of tetrahydro-β-carbolines via Pictet-Spengler reactions
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Water as an efficient medium for the synthesis of tetrahydro-β-carbolines via Pictet-Spengler reactions Water as an efficient medium for the synthesis of tetrahydro-β-carbolines via Pictet-Spengler reactions](/preview/png/5281103.png)
چکیده انگلیسی
A mild and efficient protocol for the Pictet-Spengler reaction in water using an acid catalyst has been described. The condensation of tryptophan, tryptamine, and Nb-benzyl tryptophan with different aldehydes having both electron-withdrawing and -donating substituents in the presence of a catalytic amount of TFA in water furnished tetrahydro-β-carbolines in good isolated yields. A salient feature of the water mediated Pictet-Spengler reaction was the general trend observed during the condensation of Trp-OMe and aryl/aliphatic aldehydes furnishing diastereomeric mixtures with a preference for the cis-isomer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 48, Issue 8, 19 February 2007, Pages 1379-1383
Journal: Tetrahedron Letters - Volume 48, Issue 8, 19 February 2007, Pages 1379-1383
نویسندگان
Biswajit Saha, Sunil Sharma, Devesh Sawant, Bijoy Kundu,