A versatile solid-phase synthesis of 3-aryl-1,2,4-oxadiazolones and analogues

We report here a new method to load acidic heterocyclic compounds on an alcohol resin using Mitsunobu conditions. To illustrate the utility of this procedure, iodophenyl derivatives were anchored on the same resin and a subsequent diversification using a Sonogashira coupling produced a small array of novel (arylethynyl)-phenyl-1,2,4-oxadiazol-5-ones.