Ugi/Smiles access to pyrazine scaffolds

New pyrazine and quinoxaline scaffolds were obtained via an Ugi/Smiles four-component coupling of pyrazinone or quinoxalinone derivatives with isocyanides, aldehydes, and primary amines.

New pyrazine and quinoxaline scaffolds were obtained through Ugi-Smiles coupling of pyrazinones or quinoxalinones with isocyanides, aldehydes, and primary amines.