A heterogeneous strong basic Mg/La mixed oxide catalyst for efficient synthesis of polyfunctionalized pyrans

An efficient synthesis of polyfunctionalized 4H-pyrans is carried out in one pot through condensation of an aldehyde, malononitrile, and an active methylenic diketo compound using a heterogeneous strong basic Mg/La mixed oxide catalyst. The protocol offers advantages in terms of higher yields, short reaction times, and mild reaction conditions, with reusability of the catalyst.

An efficient, heterogeneous strong basic Mg/La catalyst is studied for the synthesis of polyfunctionalized pyran derivatives in a single step by simple condensation of an aldehyde, malononitrile, and diketoesters. The reaction is operated under mild conditions and the catalyst can be recycled.