کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5281920 | 1385681 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nucleophilic substitution with amines: dihydro-1,2,4,5-tetrazines are more useful precursors than 1,2,4,5-tetrazines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Nucleophilic substitution with amines: dihydro-1,2,4,5-tetrazines are more useful precursors than 1,2,4,5-tetrazines Nucleophilic substitution with amines: dihydro-1,2,4,5-tetrazines are more useful precursors than 1,2,4,5-tetrazines](/preview/png/5281920.png)
چکیده انگلیسی
A one step synthesis of (di)alkylamino-substituted 1,2,4,5-tetrazines direct from 3,6-disubstituted-1,2-dihydro-1,2,4,5-tetrazine precursors is described. A comparative study revealed that the described method not only avoids the up-to-now required oxidation step but also lower reaction times and/or temperatures compared to usual protocols. The efficiency of the reaction was highlighted by a practical synthesis of 3,6-bis(methylamino)-1,2,4,5-tetrazine using aqueous methylamine. Other primary and secondary amines were also found to give disubstitution products when reacted with 3,6-bis(methylsulfanyl)-1,2,4,5-dihydrotetrazine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 17, 21 April 2008, Pages 2748-2751
Journal: Tetrahedron Letters - Volume 49, Issue 17, 21 April 2008, Pages 2748-2751
نویسندگان
Arnaud Cutivet, Emmanuel Leroy, Eric Pasquinet, Didier Poullain,