A one-pot organocatalytic asymmetric entry to tetrahydrothioxanthenones

A simple catalytic asymmetric synthesis of tetrahydrothioxanthenones is presented. The organocatalytic enantioselective domino reactions between 2-mercaptobenzaldehyde and α,β-unsaturated cyclic ketones proceed with excellent chemoselectivity to give the corresponding tetrahydrothioxanthenones in high yields and moderate to good enantioselectivities.