Reductive acylation of 2- and 3-nitropyrroles-efficient syntheses of pyrrolylamides and pyrrolylimides

An efficient one-pot synthesis of pyrrolylamides and pyrrolylimides is described under mild reaction conditions by the catalytic hydrogenation of 2- and 3-nitropyrroles.

Both 2- and 3-nitropyrroles are reductively acylated under catalytic hydrogenation conditions in the presence of alicyclic and cyclic carboxylic acid anhydrides to afford the corresponding N-acylated aminopyrroles.