Ti(II)-mediated domino cyclization of 2-functionalized 1-halo-2,n-enynes (n = 7, 8) to bicyclic compounds

The reaction of 2-functionalized 1-halo-2,n-enynes (n = 7 or 8) with a divalent titanium reagent, Ti(O-i-Pr)4/2i-PrMgCl, proceeded in a domino fashion to afford bicyclic compounds in good yields.

The reaction of 2-functionalized 1-halo-2,n-enynes with Ti(O-i-Pr)4/2i-PrMgCl proceeded in a domino fashion to yield bicyclic compounds.