Aminohydroxylation and dihydroxylation of 4-aryl-1,2,5,6-tetrahydropyridines

Substituted 3-amino-4-aryl-4-hydroxypiperidines and 4-aryl-3,4-dihydroxypiperidines are synthesized in the modest overall yields starting from the regio- and stereoselective trans-aminohydroxylation and dihydroxylation of 4-aryl-1,2,5,6-tetrahydropyridines via CAN-mediated oxidative addition and hydrogenation.