Microwave-induced one-pot synthesis of 4-[3-(aryl)-1,2,4-oxadiazol-5-yl]-butan-2-ones under solvent free conditions

The synthesis of 4-(3-aryl-1,2,4-oxadiazol-5-yl)-butan-2-ones (5a-l) formed from methyl levulinate (4) and arylamidoximes (1a-l) is described. The reaction was carried out under solvent free microwave irradiation conditions in much shorter time and in yields comparable with the yields obtained by conventional method.