کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5283065 | 1385706 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
NMR study of 13C-kinetic isotope effects at 13C natural abundance to characterize oxidations and an enzyme-catalyzed reduction
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: NMR study of 13C-kinetic isotope effects at 13C natural abundance to characterize oxidations and an enzyme-catalyzed reduction NMR study of 13C-kinetic isotope effects at 13C natural abundance to characterize oxidations and an enzyme-catalyzed reduction](/preview/png/5283065.png)
چکیده انگلیسی
13C-kinetic isotope effects (KIEs) of four cinnamyl alcohol oxidations and a xylose reductase-catalyzed cinnamyl aldehyde reduction have been determined by 13C NMR using competition reactions with reactants at natural 13C-abundance. Differences in KIEs among oxidations indicate dissimilarities between the respective hydrogen transfers. Their mechanistic implications are discussed. A low primary KIE of the enzymatic reduction is consistent with a kinetically complex mechanism in which steps other than the chemical step of hydride transfer from NADH are slow.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 47, Issue 24, 6 June 2006, Pages 4045-4049
Journal: Tetrahedron Letters - Volume 47, Issue 24, 6 June 2006, Pages 4045-4049
نویسندگان
Lothar Brecker, Marion F. Kögl, Catrin E. Tyl, Regina Kratzer, Bernd Nidetzky,