A comparative study of the multicomponent Ugi reactions of an oxabicycloheptene-based β-amino acid in water and in methanol

The synthesis of oxabicyclo β-lactam derivatives was accomplished, starting from di-exo-3-amino-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid, observing the solution effect of pure water and methanol.