کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5284498 | 1385738 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of oligonucleotides containing an O6-G-alkyl-O6-G interstrand cross-link
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of oligonucleotides containing an O6-G-alkyl-O6-G interstrand cross-link Synthesis of oligonucleotides containing an O6-G-alkyl-O6-G interstrand cross-link](/preview/png/5284498.png)
چکیده انگلیسی
A methodology to synthesize oligonucleotides containing an alkyl interstrand cross-link between the two O6 atoms of deoxyguanosine has been developed. This cross-link is designed to serve as a stable structural mimic of the lesion formed in duplex DNA with the bifunctional alkylating agent hepsulfam. The O6-alkyl coupling is performed via a Mitsunobu reaction between a nucleoside and mono-protected 1,7-heptanediol. Solid-phase oligonucleotide synthesis using a nucleoside bis-phosphoramidite allows for the assembly of the cross-linked duplex. Sufficient quantities of this cross-linked duplex were obtained for various structural and biological investigations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 47, Issue 51, 18 December 2006, Pages 9125-9128
Journal: Tetrahedron Letters - Volume 47, Issue 51, 18 December 2006, Pages 9125-9128
نویسندگان
Christopher J. Wilds, Jason D. Booth, Anne M. Noronha,