TiF4-mediated biomimetic alkylation-cyclization cascade reaction of 2-trimethylsilylmethyl-1,5-dienes with aldehydes

Titanium tetrafluoride promotes the addition of aldehydes to 2-trimethylsilylmethyl-1,5-dienes with concomitant biomimetic cyclization, affording 1,3-cis-disubstituted methylenecyclohexanes in good yields and high selectivity.