Amphiphilic chiral receptor as efficient chiral solvating agent for both lipophilic and hydrophilic carboxylic acids

Two amphiphilic chiral receptors 2a and 2b were designed and synthesized. Both are efficient chiral solvating agents for chiral carboxylic acid. In particular, 2a is an excellent CSA not only for lipophilic guests, but also for some hydrophilic guests. It is the first CSA for the direct determination of the enantiomeric composition of hydrophilic hydroxylated acid in protic polar solvent.