کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5284682 1385742 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biginelli-like reaction with dialkyl acetone-1,3-dicarboxylates: a remarkable case of steric control
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Biginelli-like reaction with dialkyl acetone-1,3-dicarboxylates: a remarkable case of steric control
چکیده انگلیسی
A Biginelli-type condensation is described using dialkyl acetone-1,3-dicarboxylates as active methylene compounds for the preparation of monastrol analogues. Unexpectedly, the reaction with salicylaldehyde formed two different products depending on the ester alkyl group. This product dichotomy was found to be caused by the steric effects exerted by the alcohol terminus of the ester group in the active methylene component. Previous controversial results as to the structure of the Biginelli product 3 are also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 21, 19 May 2008, Pages 3520-3523
نویسندگان
, , ,