Zygosporamide, a cytotoxic cyclic depsipeptide from the marine-derived fungus Zygosporium masonii

A new cyclic depsipeptide, composed of both d- and l-amino acids, was characterized from a marine-derived isolate of the fungus Zygosporium masonii. Zygosporamide possesses highly selective cytotoxicity in numerous cancer cell lines.