Synthesis of novel isoxazole-linked steroidal glycoconjugates-an application of a novel steroidal nitrile oxide

Isoxazole-linked steroidal glycoconjugates are prepared by 1,3-dipolar cycloaddition reactions of an in situ generated and hitherto unknown steroidal nitrile oxide with appropriate propargyl ethers of sugars. The methodology provides a novel vector in the form of an easily accessible nitrile oxide having the ability to couple with a host of biomolecules, thus offering a new pathway to construct biologically significant steroidal conjugates.