Diastereoselective Petasis Mannich reactions accelerated by hexafluoroisopropanol: a pyrrolidine-derived arylglycine synthesis

Pyrrolidine-derived arylglycines have been synthesized via a diastereoselective Petasis boronic acid Mannich reaction. Use of hexafluoroisopropanol as a co-solvent dramatically reduces reaction times, providing a practical room temperature process.