Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex

Three novel anti-angiogenic steroidal alkaloids, cortistatins J (1), K (2), L (3), have been isolated from the Indonesian marine sponge Corticium simplex. Cortistatin J showed cytostatic anti-proliferative activity against HUVECs at 8 nM, with 300-1000-fold selective index.