The highly enantioselective Diels-Alder reaction of 1,2-dihydropyridine using chiral cationic palladium-phosphinooxazolidine catalyst for the synthesis of chiral isoquinuclidines

The DA reaction of 1-phenoxy-1,2-dihydropyridine with 1-substituted 2-acryloyl-pyrazolidin-3-ones using cationic chiral Pd-phosphinooxazolidine catalyst afforded chiral isoquinuclidines with an excellent optical purity (up to 97% ee).