Synthesis of 5-aryltriazole ribonucleosides via Suzuki coupling and promoted by microwave irradiation

Aryltriazole nucleosides with various aromatic groups in the 5-position on the triazole ring were synthesized and characterized with the aim to develop novel triazole nucleosides. The aromatic groups were introduced into the triazole ring via a Suzuki reaction starting with bromotriazole nucleoside. Microwave irradiation significantly promoted the Suzuki coupling, quickly giving clean products with good to excellent yields.