کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5288897 | 1385844 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Facile preparation of difluoromethyl- and monofluoromethyl-containing amides via Ritter reaction
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Both secondary and tertiary difluoromethylated carbinols were found to readily react with acetonitrile under the catalysis of concentrated sulfuric acid to give the corresponding difluoromethylated acetamides in good yields, which is remarkably more efficient than the previously reported Ritter reactions with corresponding trifluoromethylated carbinols. Similarly, monofluoromethylated and (benzenesulfonyl)difluoromethylated carbinols have shown good reactivity in the Ritter reactions. Since the acetamides can be mildly deacetylated to give amines, the present methodology provides a convenient way for the synthesis of both difluoromethyl- and monofluoromethyl-containing amines starting from simple carbonyl compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 47, Issue 38, 18 September 2006, Pages 6753-6756
Journal: Tetrahedron Letters - Volume 47, Issue 38, 18 September 2006, Pages 6753-6756
نویسندگان
Jun Liu, Chuanfa Ni, Ya Li, Laijun Zhang, Guanyu Wang, Jinbo Hu,