Enzymatic formation of pyrrole-containing novel cyclic polyprenoids by bacterial squalene:hopene cyclase

2-(Farnesyldimethylallyl)pyrrole was enzymatically converted to a 10:1 mixture of a tricyclic and a bicyclic unnatural novel polyprenoids by recombinant squalene:hopene cyclase from Alicyclobacillus acidocaldarius.