کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5291949 | 1385917 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Syntheses and evaluation of the bioluminescent activity of (S)-Cypridina luciferin and its analogs
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Syntheses and evaluation of the bioluminescent activity of (S)-Cypridina luciferin and its analogs Syntheses and evaluation of the bioluminescent activity of (S)-Cypridina luciferin and its analogs](/preview/png/5291949.png)
چکیده انگلیسی
Cypridina luciferin is the substrate in the bioluminescence of a luminous ostracod Cypridina (Vargula) hilgendorfii. Cypridina luciferin contains a chiral center in the sec-butyl moiety. Here, we report a convenient method for the preparation of (S)-Cypridina luciferin by the condensation of (S)-1,1-diethoxy-3-methylpentan-2-one with ethioluciferin. The light yield of the synthesized (S)-luciferin in the presence of Cypridina luciferase was about 1.7 times as active as that of racemic form. Furthermore, several luciferin analogs prepared by the same condensation with different α-ketoacetal derivatives showed moderate light yield with Cypridina luciferase. These readily available Cypridina luciferin and analogs are applicable to the bioluminescent detection of Cypridina luciferase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 47, Issue 5, 30 January 2006, Pages 753-756
Journal: Tetrahedron Letters - Volume 47, Issue 5, 30 January 2006, Pages 753-756
نویسندگان
Chun Wu, Kosei Kawasaki, Satoru Ohgiya, Yoshihiro Ohmiya,