Chemoselective deprotection of N-Boc group in amino acids and peptides by bismuth(III) trichloride

N-Boc group was selectively deprotected in excellent yields using bismuth(III) trichloride in a mixed solvent of acetonitrile and water (50:1, v/v) at 55 °C in the presence of acid-labile and/or easily alkylated groups.