Synthetic approach to lipid A: Preparation of phosphorylated disaccharides containing (R)-3-hydroxyacyl and (R)-3-acyloxyacyl groups

A synthetic route was established to construct the proposed structure of lipid A which consists of β (1-6) glucosamine disaccharide 1,4′-diphosphate O,N-acylated with (R)-3-hydroxy- or (R)-3-acyloxytetradecanoic acid.