کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5349670 1503644 2014 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxicity of protein corona-graphene oxide nanoribbons on human epithelial cells
ترجمه فارسی عنوان
سمیت سلولهای نانوروبین اکسید کورونا-گرافن بر روی سلول های اپیتلیال انسان
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
چکیده انگلیسی
Graphene oxide nanoribbons (GONRs) were synthesized using an oxidative unzipping of multi-walled carbon nanotubes. The interactions of the GONRs with various concentrations of fetal bovine serum or human plasma serum indicated that the GONRs were functionalized substantially by the albumin originated from the two different protein sources. Then, concentration-dependent cytotoxicity of the protein-functionalized GONRs on human epithelial cells was studied. Although the GONRs with concentrations ≤50 μg/mL did not exhibit significant cytotoxicity on the cells (with the cell viability >85%), the concentration of 100 μg/mL exhibited significant cytotoxicity including prevention of cell proliferation and induction of cell apoptosis. These results can provide more in-depth understanding about cytotoxic effects of graphene nanostructures which can be functionalized by the proteins of media.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 320, 30 November 2014, Pages 596-601
نویسندگان
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