کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5358114 1503648 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Self-assembly of thermoresponsive nanocomposites and their applications for sensing daunorubicin with DNA
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Self-assembly of thermoresponsive nanocomposites and their applications for sensing daunorubicin with DNA
چکیده انگلیسی
Poly(N-isopropylacrylamide)-co-poly(methylmethacrylate) (PNIPAM-co-PMMA) nanofibers were fabricated by electrospinning. The titanium dioxide (TiO2) nanoparticles that grafted with thermoresponsive poly(N-isopropylacrylamide) (PNIPAM-gTiO2) were synthesized in our previous report (Gong et al., J. Mater. Chem. 22 (2012) 16872-16879). The blends of PNIPAM-co-PMMA nanofibers with PNIPAM-g-TiO2 nanoparticles (PNIPAM-g-TiO2/PNIPAM-co-PMMA) have been characterized and utilized as detection for daunorubicin. The biorecognition of daunorubicin was measured by electrochemical analysis. Because of the surface grafting polymer, both the nanocomposites of PNIPAM-g-TiO2/PNIPAM-co-PMMA and the PNIPAM-g-TiO2 nanoparticles have remarkable enhancement effect on the biorecognition of daunorubicin. Moreover, with the adding DNA, the biorecognition of the daunorubicin can be enhanced from 4% to 31.1%. It was found the self-assembly process occurred amongst the nanocomposites, daunorubicin and the DNA as the temperatures above the critical solution temperature (LCST) of the composites. These are suggested to be the potential valuable applications of sensor in the drug bioanalysis fields.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 316, 15 October 2014, Pages 194-201
نویسندگان
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