کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5363584 | 1388303 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ToF-SIMS PC-DFA analysis of prostate cancer cell lines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Three closely related cancer cell lines have been analysed with ToF-SIMS using a C60+ primary ion beam. Principal component-discriminant function analysis (PC-DFA) has been applied for spectral classification. Various spectral pre-processing methods are discussed and assessed for optimum discrimination of this data set. The sum-normalised PC-DFA spectral model produced sensitivities as high as 83.3% and specificities as high as 100% at the 99% confidence limit. At this confidence limit only one errant spectrum was misclassified. The resulting loadings plots suggest that a range of lipid and amino-acid related signals are responsible for the cell line discrimination.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 255, Issue 4, 15 December 2008, Pages 1084-1087
Journal: Applied Surface Science - Volume 255, Issue 4, 15 December 2008, Pages 1084-1087
نویسندگان
M.J. Baker, E. Gazi, M.D. Brown, N.W. Clarke, J.C. Vickerman, N.P. Lockyer,