کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5369347 | 1388428 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effect of moisture content on solid-state interaction at the interface between magnesium stearate and captopril Effect of moisture content on solid-state interaction at the interface between magnesium stearate and captopril](/preview/png/5369347.png)
A grinding process was used to accelerate the solid-state interaction at the interface between magnesium stearate (MgSt) and captopril (CAP) in the presence or absence of water. The 110 °C-preheated MgSt/CAP or MgSt/CAP ground mixture showed a 5.06% (w/w) or 6.07% (w/w) water content, respectively, which was >4.29% (w/w) for the original MgSt alone. The increased water content in each ground mixture was due to the atmospheric absorption of water caused by grinding. A small infrared (IR) peak at 1562 cmâ1 appeared in the IR spectrum of the 110 °C-preheated MgSt/CAP ground mixture, whereas a stronger IR peak at 1541 cmâ1 with a shoulder at 1556 cmâ1 was observed for the MgSt/CAP ground mixture. These IR peaks were possibly related to the solid-state interaction at the interface between MgSt and CAP via hydrogen bonding of adsorbed water. However, an excess of water added in the MgSt/CAP ground mixture could exacerbate the solid-state interaction of MgSt and CAP to form a stearic acid as evidenced by the IR peak at 1705 cmâ1. This may be due to the neutralization between basic MgSt and acidic CAP. In addition, thermal Fourier transform infrared (FTIR) microspectroscopy also confirmed that the thermal-dependent dehydration process might alter the IR peak intensity of MgSt/CAP ground mixtures.
Journal: Applied Surface Science - Volume 255, Issue 5, Part 2, 30 December 2008, Pages 2782-2786