کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5370908 1503918 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship between structural composition and material properties of polymorphic hIAPP fibrils
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Relationship between structural composition and material properties of polymorphic hIAPP fibrils
چکیده انگلیسی


- This study shows the structural characteristic of polymorphic hIAPP fibrils via constant force steered molecular dynamics simulations.
- Stacking direction and arrangement of beta strands affects the elastic modulus of hIAPP fibrils.
- The antiparallel model is found to have a higher elastic modulus compared to that of the parallel model.

Amyloid proteins are misfolded, denatured proteins that are responsible for causing several degenerative and neuro-degenerative diseases. Determining the mechanical stability of these amyloids is crucial for understanding the disease mechanisms, which will guide us in treatment. Furthermore, many research groups recognized amyloid proteins as functional biological materials that can be used in nanosensors, bacterial biofilms, coatings, etc. Many in vitro studies have been carried out to determine the characteristics of amyloid proteins via force spectroscopy methods, atomic force microscopy, and optical tweezers. However, computational methods (e.g. molecular dynamics and elastic network model) not only reveal the mechanical properties of the amyloid proteins, but also provide more in-depth information about the amyloids by presenting a visualization of their conformational changes. In this study, we evaluated the various material properties and behaviors of four different polymorphic structures of human islet amyloid polypeptide (hIAPP) by using steered molecular dynamics (SMD) simulations under tensile conditions. From our results, we examined how these mechanical properties may differ with respect to the structural formation of amyloid proteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biophysical Chemistry - Volume 199, April 2015, Pages 1-8
نویسندگان
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