Kinetics of aggregation of UV-irradiated glyceraldehyde-3-phosphate dehydrogenase from rabbit skeletal muscle. Effect of agents possessing chaperone-like activity

► An aggregation test system based on aggregation of UV-irradiated GAPDH was proposed. ► The test system allows detecting the effects of various agents exclusively on the stage of aggregation of unfolded protein. ► The protective effect of α-crystallin and 2-hydroxypropyl-β-cyclodextrin on aggregation of UV-irradiated GAPDH was studied.