کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5371820 | 1503971 | 2008 | 9 صفحه PDF | دانلود رایگان |

A mathematical model is proposed to illustrate the activation of STIM1 (stromal interaction molecule 1) protein, the assembly and activation of calcium-release activated calcium (CRAC) channels in T cells. In combination with De Young-Keizer-Li-Rinzel model, we successfully reproduce a sustained Ca2+ oscillation in cytoplasm. Our results reveal that Ca2+ oscillation dynamics in cytoplasm can be significantly affected by the way how the Orai1 CRAC channel are assembled and activated. A low sustained Ca2+ influx is observed through the CRAC channels across the plasma membrane. In particular, our model shows that a tetrameric channel complex can effectively regulate the total quantity of the channels and the ratio of the active channels to the total channels, and a period of Ca2+ oscillation about 29Â s is in agreement with published experimental data. The bifurcation analyses illustrate the different dynamic properties between our mixed Ca2+ feedback model and the single positive or negative feedback models.
Journal: Biophysical Chemistry - Volume 136, Issues 2â3, August 2008, Pages 87-95